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Chronic relapsing inflammatory optic neuropathy : ウィキペディア英語版
Chronic relapsing inflammatory optic neuropathy


Chronic relapsing inflammatory optic neuropathy (CRION), sometimes called chronic relapsing inflammatory optic neuritis, is a form of recurrent optic neuritis that is steroid responsive.〔Kidd D, Burton B, Plant GT, Graham EM. Chronic relapsing inflammatory optic neuropathy (CRION). Brain : a journal of neurology. Feb 2003;126(Pt 2):276-284〕 Patients typically present with pain associated with visual loss.〔 CRION is a diagnosis of exclusion, and other demyelinating, autoimmune, and systemic causes should be ruled out.〔Petzold A, Plant GT. Chronic relapsing inflammatory optic neuropathy: a systematic review of 122 cases reported. Journal of neurology. Jan 2014;261(1):17-26.〕 Early recognition is crucial given risks for severe visual loss and because it is treatable with immunosuppressive treatment such as steroids.〔 Relapse that occurs after reducing or stopping steroids is a characteristic feature 〔
==Pathogenesis==
The etiology remains unknown.〔 Given that CRION is responsive to immunosuppressive treatment, it may be immune-mediated.〔 CRION has been classified as an autoimmune process but this description is not established with certainty and there is no known associated autoimmune antibody 〔〔Petzold A, Plant GT. Diagnosis and classification of autoimmune optic neuropathy. Autoimmunity reviews. Apr-May 2014;13(4-5):539-545〕

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